Shopping Cart

Your shopping cart is currently empty

GSK-LSD1 dihydrochloride

Name: GSK-LSD1 dihydrochloride
Brand: TargetMol
SKU: T2315
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T2315Cas No. 2102933-95-7

Alias GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)

GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).

GSK-LSD1 dihydrochloride

😃Good

Purity: 98.72%

Catalog No. T2315Alias GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)Cas No. 2102933-95-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
2 mg	$48	In Stock	In Stock
5 mg	$65	In Stock	In Stock
10 mg	$105	In Stock	In Stock
25 mg	$221	In Stock	In Stock
50 mg	$335	In Stock	In Stock
100 mg	$549	In Stock	In Stock
500 mg	$1,170	-	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.72%

Color:Yellow

Resource Download

COA HPLC LCMS HNMR

Product Introduction

Bioactivity

Description	GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).
Targets&IC50	LSD1:16 nM
In vitro	GSK-LSD1 induces gene expression changes in cancer cell lines with average EC50 of < 5 nM and inhibits cancer cell line growth with average EC50 of < 5 nM. [1]
Synonyms	GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)

Chemical Properties

Molecular Weight	289.24
Formula	C₁₄H₂₂Cl₂N₂
Cas No.	2102933-95-7
Smiles	Cl.Cl.C1[C@@H](NC2CCNCC2)[C@@H]1c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (86.43 mM), Sonication is recommended.

H2O: 50 mg/mL (172.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.4573 mL	17.2867 mL	34.5734 mL	172.8668 mL
5 mM	0.6915 mL	3.4573 mL	6.9147 mL	34.5734 mL
10 mM	0.3457 mL	1.7287 mL	3.4573 mL	17.2867 mL
20 mM	0.1729 mL	0.8643 mL	1.7287 mL	8.6433 mL
50 mM	0.0691 mL	0.3457 mL	0.6915 mL	3.4573 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0346 mL	0.1729 mL	0.3457 mL	1.7287 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc